Clinical Proof
Skincare Product Innovation
At ZO® Skin Health, we believe that the only way to achieve optimal skin health is through the power of science. Founded by world-renowned dermatologist Dr. Zein Obagi, we push the boundaries of medical grade skincare by providing the most innovative skincare products powered by cutting-edge formulas and technologies. Our products and protocols are clinically recognized for their exceptional efficacy as some of the best skin care for aging skin – suitable for maintaining skin health for anyone, regardless of age, ethnicity, unique skin condition or skin type.
Proprietary Technologies
ZO® Skin Health’s technological expertise sets us apart. Our proprietary technologies are core to the development of formulations that achieve superior outcomes. ZO® technologies are multi-modal, allowing for the most comprehensive approach to skin health, and are always paired with a delivery system that enables greater penetration and precision. From skin firming ZCORE™ to complete skin protection with Triple- Spectrum Protection® and our award-winning retinol skin brightener formulations, our products and protocols address the most serious skin concerns at every stage of life.





Research + Development
ZO® Skin Health’s Research and Development team focuses on finding unique ingredients that work synergistically to deliver innovative products that our physicians and patients expect from a medical grade skincare brand. Through a combination of professional collaborations, higher education partnerships and unrivaled technical expertise, our R&D team continues to deliver exceptional industry-leading products and protocols for patent-worthy results.
Clinical Studies
ZO® Skin Health’s extensive clinical studies demonstrate the exceptional efficacy of the ZO®Skin Health portfolio of products and protocols. Capturing real results from real patients, our scientific analyses demonstrate our ongoing commitment to the ZO® philosophy that skin health can and should be supported by science.
Hydrating Crème
Hydration
89% of patients showed significant improvement in skin hydration by week 4.
Redness
70% of patients showed significant improvement in the appearance of redness by week 8.
Texture + Smoothness
100% of patients showed significant improvement in texture and smoothness by week 8.
Itching
82% of patients reported diminished itching due to increased hydration by week 8.
Firming Serum
Elasticity
Firming Serum is clinically proven to visibly improve skin’s elasticity.
88% elasticity improvement was measured at 12 weeks.
Firmness
Firming Serum is clinically proven to improve the appearance of firmness.
97% of participants showed significant improvement in skin firmness by week 12.
Sagging
Firming Serum is clinically proven to improve the appearance of sagging skin.
93% of participants showed significant improvement in the appearance of both mid-face and jawline skin sagging by week 12.
Wrinkle + Texture Repair
Hydration
Wrinkle + Texture Repair is clinically proven to improve the skin’s ability to retain hydration.
Lines + Wrinkles
Wrinkle + Texture Repair is clinically proven to improve the appearance of lines and wrinkles.
98% of participants showed improvement in the appearance of crow’s feet and facial fine lines by week 12.
Texture
Wrinkle + Texture Repair is clinically proven to improve the appearance of smooth texture.
93% of participants showed improvement in skin texture by week 12.